fmoc-N-methyl-D-valine

fmoc-N-methyl-D-valine - Names and Identifiers

Nombre	fmoc-N-methyl-D-valine
Sinónimos	Fmoc-N-Me-D-Val-OH Fmoc-D-N-Me-Ala-OH Fmoc-D-N-Me-Val-OH fmoc-N-methyl-D-valine N-ALPHA-FMOC-N-ALPHA-METHYL-D-VALINE N-(9-Fluorenylmethyloxycarbonyl)-N-methyl-D-valine N-[(9H-fluoren-9-ylmethoxy)carbonyl]-N-methyl-D-valine N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-N-ALPHA-METHYL-D-VALINE N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-N-ALPHA-METHYL-D-VALINE (R)-2-((((9H-Fluoren-9-yl)Methoxy)carbonyl)(Methyl)aMino)-3-Methylbutanoic acid
CAS	103478-58-6
InChI	InChI=1/C21H23NO4/c1-13(2)19(20(23)24)22(3)21(25)26-12-18-16-10-6-4-8-14(16)15-9-5-7-11-17(15)18/h4-11,13,18-19H,12H2,1-3H3,(H,23,24)/t19-/m1/s1

fmoc-N-methyl-D-valine - Physico-chemical Properties

Fórmula Molecular	C21H23NO4
Masa Molar	353.41
Densidad	1.214 ± 0.06 g / cm3 (predecido)
punto Boling	527.6±29.0 °C(Predicted)
Punto Flash	272.9°C
Presión de vapor	5.83E-12mmHg at 25°C
Apariencia	Sólido
PKa	3.92±0.10(Predicted)
Condición de almacenamiento	Sealed in dry,2-8°C
Índice de refracción	1.587
MDL	MFCD00153396

fmoc-N-methyl-D-valine - Risk and Safety

Descripción de seguridad	S22 - No inhalar polvo. S24 / 25 - evite el contacto con la piel y los ojos.
WGK Alemania	3
FLUKA BRAND F CODES	10
Clase de peligro	IRRITANT

fmoc-N-methyl-D-valine - Introduction

Fmoc-N-Methyl-D-Valine is a chemical compound with the following properties:

1. Appearance: A white to light yellow crystalline solid.
2. Solubility: Soluble in some organic solvents, such as dimethylformamide (DMF), dichloromethane, methanol, etc.
3. Stability: It is relatively stable at room temperature, but it will decompose under high temperature, strong acid or strong alkali conditions.

Fmoc-N-methyl-D-valine is commonly used in the field of biochemistry and medicinal chemistry, the main uses include:

1. Peptide synthesis: As a protecting group in peptide synthesis, the hydroxyl functional group of D-valine is protected so that the peptide chain can be selectively synthesized during the synthesis process.
2. drug research and development: as a synthetic intermediate of active peptides or proteins, it is often used in the research and development and synthesis of new drugs.

The preparation of Fmoc-N-methyl-D-valine can generally be carried out by the following steps:

1. Reaction of N-methyl-D-valine with Fmoc-chloroformate to give Fmoc-N-methyl-D-valine ester.
2. Fmoc-N-methyl-D-valine ester is then reacted with a base (such as triethylamine) or an amino acid coupling reagent to generate Fmoc-N-methyl-D-valine.

Regarding safety information, Fmoc-N-methyl-D-valine is irritating. It is recommended to wear appropriate protective equipment during operation and avoid contact with skin and eyes. At the same time, pay attention to avoid high temperature, fire source and strong acid and alkali conditions during use or storage.