Tamoxifen Citrate

Tamoxifen is a nonsteroidal anti estrogen drug. Its structure is similar to estrogen, and there are two isomers, Z-type and E-type. Their physical and chemical properties are different, and their physiological activities are also different. Type E has weak estrogen activity, while type Z has anti estrogen effect. If there is estrogen receptor (ER) in breast cancer cells, estrogen enters the tumor cells and combines with it to promote the synthesis of DNA and mRNA of tumor cells and stimulate the growth of tumor cells. The z-isomer of tamoxifen enters the cell and competes with Er to form receptor complex, which prevents the role of estrogen and thus inhibits the proliferation of breast cancer cells. Molecular Formula: C26H29NO,C6H8O7 Molecular Weight: 563.6 CAS No.: 54965-24-1 Description Tamoxifen citrate is the trans-isomer of a triphenylethylene derivative. The pKa' is 8.85, the equilibrium solubility in water at 37°C is 0.5 mg/mL and in 0.02 N HCl at 37°C, it is 0.2 mg/mL. Application It is mainly used in patients with breast cancer with high estrogen level. Combined with androgen and other anti-tumor drugs (such as adriamycin, etc.), it can improve the curative effect, and has a good curative effect on postmenopausal advanced breast cancer. Packing and Storage Preserve in well-closed, light-resistant containers. Minimum Order One package

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