Chemical Name: Neomycin sulfateCAS No.: 1405-10-3Assay: ≥99.0% Appearance: White powder
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Neomycin sulfate Usage： Neomycin sulfate, is used as broad-spectrum antibiotic, has a good function of prevention and cure of illeness (dysentery, diarrhea, maldevelopment) dysenterywhich caused by Escherichia coli, salmonella, staphylococcus aureus, Corynebacterium diphtheriae. Neomycin sulfate Packaging and Shipping： 25KG/drum or according to clients' requirements. Neomycin sulfate Storage： in a dry and ventilated warehouse; keep away from sunshine and moisture.
| Nombre | Neomycin Sulphate |
| Sinónimos | neomix mycigient neobiotic neofracin newfrancef neo-mantlecreme Nystatin sulfate neomycinesulfate Neomycin Sulfate Neomycin Sulphate mycifradin sulfate FRADIOMYCIN SULFATE NEOMYCIN SULPHATE pure (2S,3S,4S,5S,6S)-5-amino-2-(aminomethyl)-6-[(1S,2S,3S,4R,6R)-4,6-diamino-2-[(2R,3S,4R,5S)-4-[(2S,3S,4S,5S,6R)-3-amino-6-(aminomethyl)-4,5-dihydroxy-tetrahydropyran-2-yl]oxy-3-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]oxy-3-hydroxy-cyclohexoxy]tetrahydropyran-3,4-diol,sulfuric acid |
| CAS | 1405-10-3 |
| EINECS | 215-773-1 |
| InChI | InChI=1/C23H46N6O13.H2O4S/c24-2-7-13(32)15(34)10(28)21(37-7)40-18-6(27)1-5(26)12(31)20(18)42-23-17(36)19(9(4-30)39-23)41-22-11(29)16(35)14(33)8(3-25)38-22;1-5(2,3)4/h5-23,30-36H,1-4,24-29H2;(H2,1,2,3,4)/t5-,6-,7+,8-,9+,10+,11+,12+,13-,14-,15+,16+,17+,18+,19+,20+,21+,22+,23-;/m1./s1 |
| InChIKey | OIXVKQDWLFHVGR-VTSVPHRWSA-N |
| Fórmula Molecular | C23H48N6O17S |
| Masa Molar | 712.72 |
| Punto de fusión | >187°C (dec.) |
| punto Boling | 1046.1°C at 760 mmHg |
| Rotación específica (alfa) | D20 +54° (c = 2 in H2O) |
| Punto Flash | 56℃ |
| Disolución del agua | Soluble in water |
| Solubilidad | H2O: 50mg/mL As a stock solution. Stock solutions should be filter sterilized and stored at 2-8°C. Stable at 37°C for 5 days. |
| Presión de vapor | 0mmHg at 25°C |
| Apariencia | White to light yellow powder |
| color | white to slightly yellow |
| Merck | 14,6454 |
| PH | 5.0-7.5 (50g/l, H2O, 20℃) |
| Condición de almacenamiento | 2-8°C |
| Estabilidad | Estable. Incompatible con agentes oxidantes fuertes. |
| Sensible | Sensitive to light and humidity |
| Índice de refracción | 56 ° (C=10, H2O) |
| MDL | MFCD00077833 |
| Uso | For broad-spectrum antibiotics, Staphylococcus aureus, diphtheria and Bacillus anthracis good |
| Estudio in vitro | The Neomycin interacts preferentially with the ribozyme-substrate complex, and this interaction leads to a reduction in the rate of cleavage, by stabilizing the ground state of the complex and destabilizing the transition state of the cleavage step. Neomycin causes a conformational change in the structure of the transactivation Region (TAR), which can be detected by circular dichroism spectroscopy. Neomycin acts as a non-competitive inhibitor that can bind to the Tat-TAR complex and increase the rate constant (Koff) for the dissociation of RNA and peptides. Neomycin is the most potent of the aminoglycosides (groove binders) used to stabilize the triple helix of DNA. Neomycin stabilizes TAT, as well as the mixed-base DNA triple helix, better than the known DNA minor groove binders (which normally disrupt the triple helix) and polyamines. Neomycin stabilizes the TAT triple helix better, but can also stabilize the CGC() triple helix. Neomycin concentration-and voltage-dependent induction of partial inhibition of channels in the cytosolic and luminal surfaces. Neomycin has a greater affinity for the lumen than for the cytoplasm: the dissociation constants at zero voltage (Kb(0)) are 210.2 nM and 589.7 nM, respectively. Neomycin also showed voltage-dependent remission of inhibition at potentials greater than 60 mV. |
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