2-Hydroxy-5-methylpyridine - Names and IdentifiersName2-Hydroxy-5-methylpyridineSynonymsAKOS BB
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| Nombre | 2-Hydroxy-5-methylpyridine |
| Sinónimos | AKOS BBS-00002970 5-Methyl-2-pyridinol 6-HYDROXY-3-PICOLINE 5-METHYL-2-PYRIDINOL 5-METHYL-PYRIDIN-2-OL 2-Pyridinol,5-methyl- 5-METHYLPYRIDINE-2-ONE 5-METHYL-2(1H)PYRIDONE 5-methyl-(1H)pyridinone 5-Methyl 2-(1H)pyridinone 5-methylpyridin-2(1H)-one 5-Methyl-2(1H)pypridinone 5-METHYL-2(1H)-PYRIDINONE 5-METHYL-2(1H)PYPRIDINONE 4-methylpyridin-2(1H)-one 5-Methyl-2-(1H)pyridinone 2-Hydroxy-5-methylpyridine 5-Methyl-2-hydroxypyridine |
| CAS | 1003-68-5 91914-06-6 |
| EINECS | 213-713-9 |
| InChI | InChI=1/C6H7NO/c1-5-2-3-7-6(8)4-5/h2-4H,1H3,(H,7,8) |
| InChIKey | SOHMZGMHXUQHGE-UHFFFAOYSA-N |
| Fórmula Molecular | C6H7NO |
| Masa Molar | 109.13 |
| Densidad | 1.053±0.06 g/cm3(Predicted) |
| Punto de fusión | 183-187 °C (lit.) |
| punto Boling | 304.2±15.0 °C(Predicted) |
| Punto Flash | 170.6 °C |
| Solubilidad | DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly) |
| Presión de vapor | 0mmHg at 25°C |
| Apariencia | White to brown powder or crystal |
| color | Pale Yellow to Light Yellow |
| BRN | 107074 |
| PKa | 12.43±0.10(Predicted) |
| Condición de almacenamiento | Sellado en seco, temperatura ambiente |
| Índice de refracción | 1.551 |
| MDL | MFCD03092888 |
| Propiedades físicas y químicas |
| Símbolos de peligro | Xn - Dañino |
| Códigos de riesgo | R22 - Dañino si se traga R37/38 - Irritating to respiratory system and skin. R41 - Risk of serious damage to eyes R36/37/39 - |
| Descripción de seguridad | S26 En caso de contacto con los ojos, enjuagar inmediatamente con mucha agua y buscar asesoramiento médico. S36 - Use ropa protectora adecuada. S37 - Wear suitable gloves. |
| WGK Alemania | 3 |
| Número de aranceles | 29333990 |
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| Aplicación | 2-hydroxy-5-methylpyridine is a pharmaceutical intermediate that can be used to prepare pirfenidone. Pirfenidone is a new pyridone compound with broad-spectrum anti-fibrosis effect, which is a white or light yellow crystalline powder. It can prevent and reverse the formation of fibrosis and scars; and the drug also has a good effect in renal interstitial fibrosis, liver fibrosis and other fibrotic diseases; at the same time, it is also used in kidney disease (focal segmental glomerulosclerosis), Hypertrophic cardiomyopathy, adult type I multiple neurofibroma, adolescent type I multiple neurofibroma and plexiform neurofibroma, diabetes with kidney disease, uterine leiomyoma and other phase II clinical studies have a wide range of applications. |
| preparation | (1) mix 2-amino -5-methylpyridine, diazotization reagent and water evenly, cool to -4 ℃-3 ℃, add acidic solution for heat preservation reaction; After the reaction is complete, heat hydrolysis and cooling, and then adjust the pH to 6.5-7.5 with a mass fraction of 30% sodium hydroxide solution, the organic phase is extracted by the first solvent, dried and concentrated under reduced pressure to obtain 2-hydroxy-5-methylpyridine crude product;(2) A second solvent is added to the 2-hydroxy-5-methylpyridine crude product, heated and refluxed, cooled and crystallizated, pumped and dried to produce 2-hydroxy-5-methylpyridine pure product. |
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