2-cyanoethyl N,N,N',N'-tetraisopropyl-phosphordiamidite - Names and IdentifiersName2-cyanoethyl
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| Nombre | 2-cyanoethyl N,N,N',N'-tetraisopropyl-phosphordiamidite |
| Sinónimos | 2-cyanoethyltetraisopropylphosphorodiamidite 2-Cyanoethyl N,N,N,N-tetraisopropylphosphorodiamitide 2-cyanoethyl N,N,N',N'-tetraisopropyl-phosphordiamidite 2-Cyanoethyl N,N,N',N'-tetraisopropylphosphorodiamidite 2-cyanoethyl N,N,N',N'-tetrapropan-2-ylphosphorodiamidoite P-(2-cyanoethyl)-N,N,N',N'-tetrapropan-2-ylphosphonous diamide |
| CAS | 102691-36-1 |
| EINECS | 600-337-9 |
| InChI | InChI=1/C15H32N3P/c1-12(2)17(13(3)4)19(11-9-10-16)18(14(5)6)15(7)8/h12-15H,9,11H2,1-8H3 |
| InChIKey | RKVHNYJPIXOHRW-UHFFFAOYSA-N |
| Fórmula Molecular | C15H32N3P |
| Masa Molar | 285.408 |
| Densidad | 0.949 g/mL at 25 °C(lit.) |
| punto Boling | 365.713°C at 760 mmHg |
| Punto Flash | 174.977°C |
| Presión de vapor | 0mmHg at 25°C |
| Apariencia | liquid |
| color | colorless |
| BRN | 3590103 |
| PKa | 6.78±0.70(Predicted) |
| Condición de almacenamiento | -20°C |
| Estabilidad | Explodes When Heated |
| Sensible | moisture sensitive, store cold |
| Índice de refracción | n20/D 1.470(lit.) |
| Uso | Bis (diisopropylamino) (2-cyanoethoxy) phosphine is an important reagent for the synthesis of oligonucleotides and antisense drugs. At present, there are two methods for the synthesis of bis (diisopropylamino) (2-cyanoethoxy) phosphine: Studies have disclosed a method for preparing bis (diisopropylamino) (2-cyanoethoxy) phosphine. The method is to react dichloro (2-cyanoethoxy) phosphine with diisopropylamine for 48-72 hours to obtain bis (diisopropylamino) (2-cyanoethoxy) phosphine, the main disadvantage of this method is that the raw material dichloro (2-cyanoethoxy) phosphine is an acid chloride, which is unstable, easy to deteriorate, has a long reaction time, and is difficult to purchase, so it is not conducive to industrial production. Another method for preparing bis (diisopropylamino) (2-cyanoethoxy) phosphine is to react bis (diisopropylamino) phosphine with 3-hydroxypropiononitrile for 20 hours to obtain bis (diisopropylamino) (2-cyanoethoxy) phosphine. |
| Símbolos de peligro | XI - irritación |
| Códigos de riesgo | R5 - Heating may cause an explosion R36 / 37 / 38 - irrita los ojos, el sistema respiratorio y la piel. |
| Descripción de seguridad | S3 - Keep in a cool place. S26 En caso de contacto con los ojos, enjuagar inmediatamente con mucha agua y buscar asesoramiento médico. S36 - Use ropa protectora adecuada. |
| UN IDs | UN 1993 |
| WGK Alemania | 3 |
| FLUKA BRAND F CODES | 10-21-34 |
| Número de aranceles | 29299000 |
| Hazard Note | Irritant/May Explode on Heating |
| Clase de peligro | 8 |
| Packing Group | I |
Application Bis (diisopropylamino) (2-cyanoethoxy) phosphine is an intermediate in organic synthesis and pharmaceutical research and development. It can be used to synthesize phosphite during laboratory research Reagents.
Preparation Add 15g tris (diisopropylamino) phosphine and 200ml dichloromethane to the three-mouth bottle, stir until completely dissolved, then add 3.86g of 3-hydroxypropiononitrile and 3.80g of 1H-tetrazole, and maintain the obtained solution at a temperature of -20 ° C- 0°C for reaction for 10 hours; Then, suction filtration and desalting, saturated sodium bicarbonate washing, saturated sodium chloride washing, liquid separation, sodium sulfate drying organic phase, suction filtration, the solvent is distilled under reduced pressure to obtain a white or light yellow liquid; the oil pump distilled under reduced pressure to obtain a colorless transparent liquid bis (diisopropylamino) (2-cyanoethoxy) phosphine 7g. 51.5% molar yield.
Reagents for the synthesis of phosphorite nucleotides
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